Cyberinfrastructure is critical to accelerating discovery and innovation across all disciplines. In order to support these advances, the National Science Foundation (NSF) supports a dynamic cyberinfrastructure ecosystem composed of multiple resources including data, software, networks, high-end computing, and people. I will discuss NSF’s strategy to ensure that researchers across the U.S. have access to a diversity of these resources to continue our nation’s ability to be the discovery and innovation engine of the world. I will also provide an update on cyberinfrastructure activities within NSF, and reflect on the importance of layered CI architectures and reference models for accelerating the pace of scientific discovery.